Category: 137-40-6

In an article, author is Filatov, Alexander S., once mentioned the application of 137-40-6, HPLC of Formula: C3H5NaO2, Name is Sodiumpropionate, molecular formula is C3H5NaO2, molecular weight is 96.0604, MDL number is MFCD00002759, category is thiazolidines. Now introduce a scientific discovery about this category.

Concise Synthesis of Tryptanthrin Spiro Analogues with In Vitro Antitumor Activity Based on One-Pot, Three-Component 1,3-Dipolar Cycloaddition of Azomethine Ylides to Cyclopropenes

A simple, efficient and atom-economic method has been developed for the synthesis of complex alkaloid-like compounds with spiro-fused indolo[2,1-b]quinazoline and cyclopropa[a]pyrrolizine or 3-azabicyclo[3.1.0]hexane moieties. We have found that one-pot, three-component 1,3-dipolar cycloaddition reactions allow the desired products to be obtained from various cyclopropene derivatives with tryptanthrin-derived azomethine ylides generated in situ, in good to high yields and excellent diastereoselectivity. The possibility of ylide generation was exemplified by using alpha-amino acids (L-proline, L-4-thiazolidin-carboxylic acid) and simplest peptides (dipeptide Gly-Gly, tripeptide Gly-Gly-Gly). Quantum chemical investigations indicate that the reaction proceeds through the S-shaped azomethine ylide, the interaction of which with cyclopropenes proceeds via a less sterically hindered endo-transition state. The antitumor activity of some of spiro-tryptanthrin derivatives against erythroleukemia (K562), cervical carcinoma (HeLa) and colon carcinoma (CT26) cell lines was evaluated in vitro by MTS-assay.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 137-40-6, Name is Sodiumpropionate, molecular formula is , belongs to thiazolidines compound. In a document, author is Ekinci, Ahmet Serhat, SDS of cas: 137-40-6.

5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds (2a and 2c) were determined by the single-crystal X-ray diffraction study. Among the target compounds, 2-(4-ethoxypheny1)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentration of 12.5 mu g/mL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 137-40-6, in my other articles. SDS of cas: 137-40-6.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In an article, author is Mahmoud, M. R., once mentioned the application of 137-40-6, Formula: C3H5NaO2, Name is Sodiumpropionate, molecular formula is C3H5NaO2, molecular weight is 96.0604, MDL number is MFCD00002759, category is thiazolidines. Now introduce a scientific discovery about this category.

Synthesis of Novel 2,3-Disubstituted Quinazolin-4-(3H)-ones and Their Antibacterial Activity on the Ultra-structure of Some Pathogenic Microorganisms

A SERIES of highly functionalized quinazolin-4-ones, with different substituents at position 3, have been concisely synthesized in good yields, via the reactions of 3-amino-6-bromo-2-undecyl-quinazoline-4(3H)-one with one carbon donor phenyl isothiocyante, followed by alpha-chlorinated compounds and 1,2-dichloroethanone. Moreover, reactions of 6-bromo-2-undecyl-4H-benzo-[3,1] oxazin-4-one with different hydrazides were also examined, giving new 3-substituted quinazolin-4-one derivatives. Some of the new quinazolin-4-ones were screened against gram negative and positive bacteria and showed good to moderate antibacterial activity. Structures of all new synthesized compounds in this investigation were substantiated using spectroscopic IR, H-1-NMR and MS studies.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 137-40-6, Name is Sodiumpropionate, molecular formula is C3H5NaO2, belongs to thiazolidines compound, is a common compound. In a patnet, author is Arnold, G. -L., once mentioned the new application about 137-40-6, Recommanded Product: 137-40-6.

New azulene modified electrodes for heavy metal ions recognition

(E)-2-thioxo-5-((4,6,8-trimethylazulen-1-yl)methylene)thiazolidin-4-one (L) was electrochemically characterized by cyclic voltammetry, differential pulse voltammetry and rotating disk electrode voltammetry. PolyL modified electrode obtained by the controlled potential electrolysis was tested in solutions containing different metal ions (Cd, Pb, Cu, Hg) at increased concentrations. The best response was found for Pb (10(-7)M).

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

137-40-6, Name is Sodiumpropionate, molecular formula is C3H5NaO2, belongs to thiazolidines compound, is a common compound. In a patnet, author is Paul, Mathias, once mentioned the new application about 137-40-6, Safety of Sodiumpropionate.

Breslow Intermediates from a Thiazolin-2-ylidene and Fluorinated Aldehydes: XRD and Solution-Phase NMR Spectroscopic Characterization

The first generation and X-ray diffraction (XRD) analysis of a crystalline Breslow intermediate (BI) derived from a thiazolin-2-ylidene, that is, the aromatic heterocycle present in vitamin B-1, is reported. Key to success was the combined use of pentafluorobenzaldehyde and a thiazolin-2-ylidene carrying an enol-stabilizing dispersion energy donor as N-substituent. A so-called primary intermediate (PI) could be isolated in protonated form (pPI) as well and analyzed by XRD. Furthermore, the first stable BI derived from an aromatic thiazolin-2-ylidene and an aliphatic aldehyde (trifluoroacetaldehyde) was prepared and characterized by NMR spectroscopy in solution. When switching to a saturated thiazolidin-2-ylidene, reaction with pentafluorobenzaldehyde afforded a new BI in solution (NMR spectroscopy). Attempts to crystallize the latter BI resulted in the isolation of a novel thiazolidin-2-ylidene dimer that had undergone rearrangement to a hexahydro[1,4]-thiazino[3,2-b]-1,4-thiazine.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is an experimental science, Safety of Sodiumpropionate, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 137-40-6, Name is Sodiumpropionate, molecular formula is C3H5NaO2, belongs to thiazolidines compound. In a document, author is El-Sheshtawy, Hamdy S..

Synthesis, Structural, and Theoretical Studies of Quinazoline-2,4-dione Derivatives

New quinazolin-2,4-dione derivatives have been synthesized and fully characterized. The new derivatives were synthesized using 3-(2-imino-4-oxo-3H,4H,5H-thiazolidin-3-yl)-1H-quinazolin-2,4-dione by nucleophilic addition mechanism. DFT calculations using B3LYP/6-311++G(d,p) level of the theory were used to investigate the molecular structures and the relative stabilities of the anticipated isomers (E and Z). Both experimental and theoretical calculations confirmed the higher stability of the Z-isomers compared to the E-isomers. The former is stabilized by two intramolecular hydrogen bonds compared to only one in the latter isomer. The frontier orbital calculations (HOMO and LUMO), and the energy gap confirmed the stability of the molecules.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 137-40-6, in my other articles. Safety of Sodiumpropionate.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Application of 137-40-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 137-40-6, Name is Sodiumpropionate, SMILES is CCC(=O)[O-].[Na+], belongs to thiazolidines compound. In a article, author is Karot, Sarine Sebastian, introduce new discover of the category.

Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome

BackgroundThe replacement of the thiazolidinedione moiety with a thiazolidinone may yield antidiabetic compounds with similar pleiotropic effects. Hence, the aim of the present study was to explore the dose-related antihyperglycemic and hypolipidemic effects of two synthesized novel thiazolidin-4-one derivatives, one with a nicotinamide and the other with a p-chlorophenoxyacetamide substitution at the N3 position of the thiazolidinone ring (NAT1 and PAT1, respectively), in a rodent model of metabolic syndrome (MetS). MethodsMetabolic syndrome was induced in Wistar rats by neonatal administration of monosodium glutamate (i.p.) on 4 consecutive days followed by high-sucrose diet feeding for 6months. The effects of NAT1 (33 and 66mg/kg) and molar equivalent doses of PAT1 (40 and 80mg/kg) on relevant biochemical parameters were evaluated. Because MetS is a state of chronic low-grade inflammation, we also evaluated the effects of these compounds on proinflammatory markers, namely interleukin (IL)-6, tumor necrosis factor (TNF)-, reactive oxygen species (ROS), and nitric oxide (NO). ResultsBoth NAT1 and PAT1 attenuated hyperglycemia, hypertriglyceridemia, hypoalphalipoproteinemia, and glucose intolerance. PAT1 exhibited superior antihyperglycemic and antihypoalphalipoproteinemic effects than NAT1. However, NAT1 had a better triglyceride-lowering effect. At the lower dose tested, both compounds significantly reduced elevated malondialdehyde levels. In addition, PAT1 (80mg/kg) restored hepatic superoxide dismutase enzyme levels. There was a tendency for NAT1 and PAT1 to inhibit elevated hepatic IL-6 and TNF- levels, but the differences did not reach statistical significance. In addition, PAT1 exhibited in vitro anti-inflammatory activity by reducing proinflammatory ROS and NO levels in RAW264.7 macrophages. ConclusionsThe novel thiazolidin-4-ones NAT1 and PAT1 could be potential pleiotropic drug candidates targeting MetS.

Application of 137-40-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 137-40-6.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 137-40-6, Name is Sodiumpropionate, molecular formula is C3H5NaO2. In an article, author is El Ajlaoui, Rahhal,once mentioned of 137-40-6, Recommanded Product: 137-40-6.

Crystal structure of (Z)-3-allyl-5-(4-chlorobenzylidene)-2-sulfanylidene-1,3thiazolidin- 4-one

In the title compound, C13H10ClNOS2, the dihedral angle between the rhodanine (r. m. s. deviation = 0.008 angstrom) and 4chlorobenzylidene rings is 1.79 (11) degrees. The allyl group attached to the N atom, which lies almost perpendicular to the rhodanine ring, is disordered over two orientations in a 0.519 (13): 0.481 (13) ratio. A short intramolecular C-H center dot center dot center dot S interaction closes an S(6) ring. In the crystal, molecules are linked by pi-pi stacking interactions [centroid-centroid separation = 3.600 (15) angstrom], generating inversion dimers.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Reference of 137-40-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 137-40-6, Name is Sodiumpropionate, SMILES is CCC(=O)[O-].[Na+], belongs to thiazolidines compound. In a article, author is Hassan, Alaa A., introduce new discover of the category.

The Behavior of (cyclic-alkylidene)hydrazinecarbothioamides in Cyclization with Dimethyl acetylenedicarboxylate

A series of (Z)-methyl 2(Z)-3-substituted-2-(cycloalkylidenehydrazono)-4-oxothiazolidin-5-ylidene)-acetate derivatives were synthesized via condensation alkylidene-N-substituted hydrazinecarbothioamides with dimethyl acetylenedicarboxylate. The synthesized compounds were characterized by using different spectroscopic methods and confirmed by single crystal X-ray analysis. The behavior of (cyclic-alkylidene) hydrazinecarbothioamides in cyclization was presented. The mechanism of transformation of (Z)-methyl 2-((Z)-3-(cyclopentylideneamino)-4-oxo-2-(phenylimino)thiazolidin-5-ylidene)acetate (14) into the more stable (Z)-Methyl 2-[(Z)-2-(cyclopentylidenehydrazono)-4-oxo-3-phenylthiazolidin-5-ylidene]acetate (5a) was discussed and confirmed.

Reference of 137-40-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 137-40-6.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 137-40-6, Name is Sodiumpropionate. In a document, author is Ulusoy, Seyhan, introducing its new discovery. Recommanded Product: 137-40-6.

Quorum Sensing Inhibitor Activities of Celecoxib Derivatives in Pseudomonas aeruginosa

Background: A series of novel N-(substituted aryl/alkylcarbamothioyl)-4-[5-(4-methylphenyl)3-( trifluoromethyl)-1H-pyrazol-1-yl] benzene sulfonamides [SGK 318, 319, 320, 324, 327] and N-(3-substitutedaryl/ alkyl-4-oxo-1,3-thiazolidin-2-ylidene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamides[SGK 328, 329, 330, 334, 337] were synthesized and tested for their quorum sensing inhibitor (QSI) capacity using quorum sensing inhibitor selector 1 (QSIS1) bioassay. Findings: QSIS assay revealed that SGK 324, SGK 327 and SGK 330 have the potentials to interfere with QS system in QS inhibitor selector1 (QSIS1) reporter strain. Moreover, these compounds were found to significantly affect QS regulated elastase and biofilm productions in Pseudomonas aeruginosa PA01 strain without affecting its growth. Molecular modeling experiments suggested that SGK 330 fits within the binding site of LasR protein of P. aeruginosa. SGK 324 and 327 also bind LasR provided that they adopt a s-trans/s-cis conformation with respect to the thiourea function. Results and Conclusion: Results of this study indicated that these compounds could be developed as new QS inhibitors without killing the bacteria but as antivirulence compounds to restrict virulence of clinically important human pathogens.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com