Category: 114527-53-6

Synthetic Route of C10H11NO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Reduction of quinolinecarboxylic acids by Raney nickel. Author is Gracheva, I. N.; Tochilkin, A. I..

The heterocyclic nucleus of quinolinecarboxylic acids was reduced by Raney Ni in alkali media giving 1,2,3,4-tetrahydroquinoline-2-, -3-, -4-, -5-, -6-, and -8-carboxylic acids. Their Et esters were also prepared

There is still a lot of research devoted to this compound(SMILES：OC(=O)C1CNC2=CC=CC=C2C1)Synthetic Route of C10H11NO2, and with the development of science, more effects of this compound(114527-53-6) can be discovered.

Reference:
Thiazolidine – Wikipedia,
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Reference of 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Structure-based design of 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines as inhibitors of myeloid cell leukemia-1 (Mcl-1).

Mcl-1 has recently emerged as an attractive target to expand the armamentarium in the war on cancer. Using structure-based design, 3-carboxy-substituted 1,2,3,4-tetrahydroquinolines were developed as a new chemotype to inhibit the Mcl-1 oncoprotein. The most potent compound inhibited Mcl-1 with a Ki of 120 nM, as determined by a fluorescence polarization competition assay. Direct binding was confirmed by 2D 1H-15N HSQC NMR spectroscopy with 15N-Mcl-1, which indicated that interactions with R263 and T266, and occupation of the p2 pocket are likely responsible for the potent binding affinity. The short and facile synthetic chem. to access target mols. is expected to mediate lead optimization.

There is still a lot of research devoted to this compound(SMILES：OC(=O)C1CNC2=CC=CC=C2C1)Reference of 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, and with the development of science, more effects of this compound(114527-53-6) can be discovered.

Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β-Amino Acids.Category: thiazolidine.

Electrophilic aminations involve an umpolung of a nitrogen atom, providing an alternate, distinctive synthetic strategy. The recent advent of various designed O-substituted hydroxylamines has significantly advanced this research field. An underappreciated issue is atom economy of the transformations: The necessary activating group on the oxygen atom is left in coproduced waste. Herein, the authors describe Rh-catalyzed electrophilic amination of substituted isoxazolidin-5-ones for the synthesis of unprotected, cyclic β-amino acids featuring either benzo-fused or spirocyclic scaffolds. Using the cyclic hydroxylamines allows for retaining both nitrogen and oxygen functionalities in the product. The traceless, redox neutral process proceeds on a gram scale with as little as 0.1 mol % catalyst loading. In contrast to related electrophilic aminations in the literature, a series of mechanistic experiments suggests a unique pathway involving spirocyclization, followed by the skeletal rearrangement. The insights provided herein shed light on a nuanced reactivity of the active species, Rh-nitrenoid generated from the activated hydroxylamine, and extend the knowledge on electrophilic aromatic substitutions.

If you want to learn more about this compound(1,2,3,4-Tetrahydroquinoline-3-carboxylic acid)Category: thiazolidine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(114527-53-6).

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Thiazolidine – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity, the main research direction is CD4 mimetic small mol synthesis HIV1 infection ADCC sensitizing.Formula: C10H11NO2.

With approx. 37 million people living with HIV worldwide and an estimated 2 million new infections reported each year, the need to derive novel strategies aimed at eradicating HIV-1 infection remains a critical worldwide challenge. One potential strategy would involve eliminating infected cells via antibody-dependent cellular cytotoxicity (ADCC). HIV-1 has evolved sophisticated mechanisms to conceal epitopes located in its envelope glycoprotein (Env) that are recognized by ADCC-mediating antibodies present in sera from HIV-1 infected individuals. Our aim is to circumvent this evasion via the development of small mols. that expose relevant anti-Env epitopes and sensitize HIV-1 infected cells to ADCC. Rapid elaboration of an initial screening hit using parallel synthesis and structure-based optimization has led to the development of potent small mols. that elicit this humoral response. Efforts to increase the ADCC activity of this class of small mols. with the aim of increasing their therapeutic potential was based on our recent cocrystal structures with gp120 core.

If you want to learn more about this compound(1,2,3,4-Tetrahydroquinoline-3-carboxylic acid)Formula: C10H11NO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(114527-53-6).

Reference:
Thiazolidine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Catalytic Hydrogenation of Substituted Quinolines on Co-Graphene Composites.SDS of cas: 114527-53-6.

A set of 20 composites was prepared by pyrolysis of Co2+ complexes with 1,10-phenanthroline, melamine and 1,2-diaminobenzene. These composites were tested as the catalysts for the hydrogenation of quinolines. As shown by powder X-ray diffraction and TEM, the composites contained Co particles of several dozen nm sizes. The composition (elements content), Raman spectra X-ray photoelectron spectra parameters of the composites were analyzed. It was found that there was no distinct factor that controlled the yield of 1,2,3,4-tetrahydroquinolines in the investigated process. The yields of the resp. products were in the range 90-100%. The three most active composites were selected for scale-up and hydrogenation of a series of substituted quinolines. Up to 97% yield of 1,2,3,4-tetrahydroquinoline was obtained on a 50 g scale. Five representative substituted quinolines were synthesized on a 10-20 g scale using the Co-containing composites as the catalysts.

In some applications, this compound(114527-53-6)SDS of cas: 114527-53-6 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Thiazolidine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.Category: thiazolidine.

There is an urgent need for new, brain penetrant small mols. that target the central nervous system second stage of human African trypanosomiasis (HAT). We report that a series of novel indoline-2-carboxamides have been identified as inhibitors of Trypanosoma brucei from screening of a focused protease library against Trypanosoma brucei brucei in culture. We describe the optimization and characterization of this series. Potent antiproliferative activity was observed The series demonstrated excellent pharmacokinetic properties, full cures in a stage 1 mouse model of HAT, and a partial cure in a stage 2 mouse model of HAT. Lack of tolerability prevented delivery of a fully curative regimen in the stage 2 mouse model and thus further progress of this series.

If you want to learn more about this compound(1,2,3,4-Tetrahydroquinoline-3-carboxylic acid)Category: thiazolidine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(114527-53-6).

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Thiazolidine – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Catalytic Hydrogenation of Substituted Quinolines on Co-Graphene Composites, published in 2021-12-21, which mentions a compound: 114527-53-6, Name is 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, Molecular C10H11NO2, Formula: C10H11NO2.

A set of 20 composites was prepared by pyrolysis of Co2+ complexes with 1,10-phenanthroline, melamine and 1,2-diaminobenzene. These composites were tested as the catalysts for the hydrogenation of quinolines. As shown by powder X-ray diffraction and TEM, the composites contained Co particles of several dozen nm sizes. The composition (elements content), Raman spectra X-ray photoelectron spectra parameters of the composites were analyzed. It was found that there was no distinct factor that controlled the yield of 1,2,3,4-tetrahydroquinolines in the investigated process. The yields of the resp. products were in the range 90-100%. The three most active composites were selected for scale-up and hydrogenation of a series of substituted quinolines. Up to 97% yield of 1,2,3,4-tetrahydroquinoline was obtained on a 50 g scale. Five representative substituted quinolines were synthesized on a 10-20 g scale using the Co-containing composites as the catalysts.

Here is a brief introduction to this compound(114527-53-6)Formula: C10H11NO2, if you want to know about other compounds related to this compound(114527-53-6), you can read my other articles.

Reference:
Thiazolidine – Wikipedia,
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