Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells was written by Sun, Shuang;Oliveira, Bruno L.;Jimenez-Oses, Gonzalo;Bernardes, Goncalo J. L.. And the article was included in Angewandte Chemie, International Edition in 2018.Synthetic Route of C10H11NS2 This article mentions the following:
Photoactivated drugs provide an opportunity to improve efficacy alongside reducing side-effects in the treatment of severe diseases such as cancer. Described herein is a photoactivation decaging method of isobutylene-caged thiols through a UV-initiated thiol-ene reaction. The method was demonstrated with an isobutylene-caged cysteine, cyclic disulfide-peptide, and thiol-containing drug, all of which were rapidly and efficiently released under mild UV irradiation in the presence of thiol sources and a photoinitiator. Importantly, it is shown that the activity of histone deacetylase inhibitor largazole can be switched off when stapled, but selectively switched on within cancer cells when irradiated with non-phototoxic light. In the experiment, the researchers used many compounds, for example, (R)-4-Benzylthiazolidine-2-thione (cas: 110199-17-2Synthetic Route of C10H11NS2).
(R)-4-Benzylthiazolidine-2-thione (cas: 110199-17-2) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Synthetic Route of C10H11NS2
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com