Category: 10097-02-6

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, SMILES is CCC(CO)(CO)C(O)=O, in an article , author is Begum, Kahkashan, once mentioned of 10097-02-6, Quality Control of 2,2-Bis(hydroxymethyl)butyric acid.

Synthesis and Evaluation of Some 2-Aryl-3-[substituted pyridin-2-yl]-amino/methylamino thiazolidin-4-ones

A series of compounds incorporating thiazolidinone moiety has been synthesized and screened for their antifungal activity. 2-Aryl-3-[substituted pyridin-2-yl]-amino/methylamino thiazolidin-4-ones have been synthesized by cyclocondensation of [substituted pyridin-2-yl]-araldehydehydrazone and N-Methyl [substituted pyridin-2-yl]-araldehydehydrazone with mercapto acetic acid in dioxane. The initial reactants required for the synthesis were obtained by refluxing 2-hydrazino substituted pyridine and 2-[N-methylhydrazino]-substituted pyridine with different substituted aldehydes. These newly synthesized compounds were then screened for their fungicidal activity against Rhizoctina solani and Fusarium oxysporum. Structures of all these compounds were confirmed by H-1 NMR, IR and mass spectrum analysis. Some compounds exhibited excellent fungicidal properties.

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In an article, author is Devi, N. Saritha, once mentioned the application of 10097-02-6, Computed Properties of C6H12O4, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4, molecular weight is 148.16, MDL number is MFCD00190088, category is thiazolidines. Now introduce a scientific discovery about this category.

SYNTHESIS AND SCREENING N-(2, 4 ‘-DIOXO-1, 2-DIHYDRO-3 ‘ H-SPIRO [INDOLE-3, 2 ‘-[1,3]THIAZOLIDIN]-3 ‘-YL)-2-HYDROXYBENZAMIDES FOR ANTI-BACTERIAL ACTIVITY

A novel synthesis of N-(2, 4′-dioxo-1, 2-dihydro-3’H-spiro [indole-3, 2′-[1, 3] thiazolidin]-3’-yl)-2-hydroxybenzamide derivatives were synthesized by cyclization of isatin hydrazones with thioglycolic acid. The synthesized compounds were characterized by spectral data (IR, H-1-NMR, Mass) and evaluated for antibacterial activity against various strains of bacteria at the concentrations of 200 mu g/ml. Among the tested compounds X(i) is highly active against E. coli, X(f) is active against B. subtilis, X(h) is active against S. aureus and X(c) is active against S. typhi.

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10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4, belongs to thiazolidines compound, is a common compound. In a patnet, author is Gilani, Sadaf J., once mentioned the new application about 10097-02-6, HPLC of Formula: C6H12O4.

Benzothiazole incorporated thiazolidin-4-ones and azetidin-2-ones derivatives: Synthesis and in vitro antimicrobial evaluation

In this study, a series of novel thiazolidin-4-ones (5a-g) and azetidin-2-ones (6a-g) were synthesized from N-(6-chlorobenzo[d]thiazol-2-yl)hydrazine carboxamide derivatives of the benzothiazole class. Antimicrobial properties of the title compound derivatives were investigated against one Gram (+) bacteria (Staphylococcus aureus), three Gram (-) bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and five fungi (Candida albicans, Aspergillus niger, Aspergillus flavus, Monascus purpureus and Penicillium citrinum) using serial plate dilution method. The investigation of antibacterial and antifungal screening data revealed that all the tested compounds showed moderate to good inhibition at 12.5-200 lg/mL in DMSO. It has been observed that azetidin-2-ones derivatives are found to be more active than thiazolidin-4-ones derivatives against all pathogenic bacterial and fungal strains. (C) 2012 Production and hosting by Elsevier B.V.

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Synthetic Route of 10097-02-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, SMILES is CCC(CO)(CO)C(O)=O, belongs to thiazolidines compound. In a article, author is Safaei-Ghomi, Javad, introduce new discover of the category.

Nano-CdZr4(PO4)(6) as a reusable and robust catalyst for the synthesis of bis-thiazolidinones by a multicomponent reaction of aldehydes, ethylenediamine and thioglycolic acid

Nano-CdZr4(PO4)(6) has been used as an efficient catalyst for the preparation of bis-thiazolidinones by pseudo-five-component reaction of aldehydes, ethylenediamine and thioglycolic acid under reflux conditions in toluene. The present synthetic protocol has several advantages, such as simplicity, excellent yields, short reaction times, reusability of the catalyst and low catalyst loading. [GRAPHICS] .

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Thiazolidine – Wikipedia,
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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4. In an article, author is Zivkovic, Marijana B.,once mentioned of 10097-02-6, Name: 2,2-Bis(hydroxymethyl)butyric acid.

Anticancer potential of new steroidal thiazolidin-4-one derivatives. Mechanisms of cytotoxic action and effects on angiogenesis in vitro

The synthesis and cytotoxic activities determination of new steroidal mono- and bis(thiazolidin-4-ones) 4a-f and 5a-f have been performed. Their anticancer action was also evaluated in comparison to previously synthesized and reported corresponding steroidal thiosemicarbazones. All compounds were obtained as stereoisomeric mixtures with different configuration (E or Z) in the hydrazone moiety at the C-3 position. After several consecutive crystallizations diastereomerically pure major (5)-isomers of mono-thiazolidin-4-ones were isolated. The structure and stereochemistry of 2,4-thiazolidinedione,2-[(17-oxoandrost-4-en-3-ylidene)hydrazone] were confirmed by X-ray analysis. A pathway for the formation of thiazolidin-4-one ring was proposed. The steroid thiazolidinone derivatives examined in this study exerted selective concentration-dependent cytotoxic activities on six tested malignant cell lines. Ten out of twelve examined compounds exhibited strong cytotoxic effects on K562 cells (IC50 values from 8.5 mu M to 14.9 mu M), eight on HeLa cells (IC50 values ranging from 8.9 mu M to 15.1 mu M) while against MDA-MB-361 cells six compouds exerted similar or even higher cytotoxic action (IC50 values from 12.7 mu M to 25.6 mu M) than cisplatin (21.5 mu M) which served as a positive control. Eight of these ten compounds showed high selectivity in the cytotoxic action against HeLa and K562 cancer cell lines when compared with normal human fibroblasts MRC-5 and normal human PBMC. The study of mechanisms of the anticancer activity of the two selected compounds, mono- and bis(thiazolidin-4-one) derivatives of 19-norandrost-4-ene-3,17-dione 4a and 5a, revealed that both of these compounds induced apoptosis in HeLa cells through extrinsic and intrinsic signalling pathways. Treatment of EA.hy926 cells with sub-toxic concentrations of these compounds led to the inhibition of cell connecting and sprouting, and tube formation. The synthesized compounds exhibited poor antioxidant activity.

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Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is , belongs to thiazolidines compound. In a document, author is Hassan, Alaa A., Recommanded Product: 10097-02-6.

Synthesis of 1,3-thiazolidin-4-ones; reactivity of the thiosemicarbazone function towards dimethyl acetylenedicarboxylate

Aryl thiosemicarbazones react rapidly in a facile procedure with dimethyl acetylene-dicarboxylate to give substituted (ylidene) hydrazono(4-oxothiazolidin-5-ylidene) acetates in high yields. The synthesised compounds were characterised by spectroscopic methods and the structures confirmed by single crystal X-ray crystallography. Several mechanistic options involving nucleophilic interaction are presented.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10097-02-6, in my other articles. Recommanded Product: 10097-02-6.

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Thiazolidine – Wikipedia,
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Chemistry, like all the natural sciences, COA of Formula: C6H12O4, begins with the direct observation of nature¡ª in this case, of matter.10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, SMILES is CCC(CO)(CO)C(O)=O, belongs to thiazolidines compound. In a document, author is Stan, Catalina Daniela, introduce the new discover.

ASSESSMENT OF IN VITRO ANTIOXIDANT ACTIVITY OF SOME NEW FERULIC ACID DERIVATIVES

Aim: The in vitro antioxidant potential of new thiazolidin-4-one derivatives of ferulic acid was evaluated according to the total antioxidant activity and ferric reducing power assays. Material and methods: The ferric reducing power assay was based on the reduction of ferricyanide to ferrocyanide, which form in the presence of ferric chloride a Perl Prussian blue color complex. The total antioxidant activity assay was assessed using phosphomolybdenum method. The results were expressed as effective concentration (EC50) values and ascorbic acid was used as positive control. All determinations were performed in triplicate. Results: It was found that the activity of the tested compounds is influenced by the substituents on phenyl ring of the thiazolidine-4-one moiety. The most active compound was 1i, which contains 2,3-diOH as substituent on phenyl ring. Conclusions: A total of 10 new thiazolidin-4-one derivatives of ferulic acid were investigated for their in vitro antioxidant activity. The most active compound 1i (R=2,3-diOH) proved to be about 4 times more active than ferulic acid and comparable to ascorbic acid in both antioxidant assays.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 10097-02-6. COA of Formula: C6H12O4.

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Thiazolidine – Wikipedia,
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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4. In an article, author is Altug, Cevher,once mentioned of 10097-02-6, Quality Control of 2,2-Bis(hydroxymethyl)butyric acid.

Multicomponent synthesis of novel thiazolo[3,2-a]pyridin-8-yl-phosphonates as a model of plant growth regulator

A series of thiazolo[3,2-a]pyridin-8-yl-phosphonate derivatives have been obtained by the reaction of diethyl (E)-((4-oxothiazolidin-2-ylidene)methyl)phospohonate, malononitrile and two equivalent of various aromatic aldehydes in a multicomponent reaction with good yields. The structures of the new compounds are confirmed by spectroscopic methods (IR, H-1, C-13, P-31 NMR and HRMS). Compound diethyl-(Z)-(5-amino-6-cyano-2-(4-nitrobenzylidene)-7-(4-nitrophenyl)-3-oxo-3,7-dihydro-2H-thiazolo[3,2-a]pyridin -8-yl)phosphonate (4k) at 1mM concentration enhanced biomass plant height, number of branches and leaf area of tomato plants of at least two-fold compared to the control plants. In common bean plants, this compound enhanced the chlorophyl content and delayed senescence in comparison to the control plants. Therefore, in future studies, the compound(s) would be further tested to evaluate deeply their mode of action at physiological, biochemical and molecular level to finally enhance crop productivity of various plants.

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Electric Literature of 10097-02-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, SMILES is CCC(CO)(CO)C(O)=O, belongs to thiazolidines compound. In a article, author is Tambunan, Usman S. F., introduce new discover of the category.

In silico identification of 2-oxo-1,3-thiazolidine derivatives as novel inhibitor candidate of class II histone deacetylase (HDAC) in cervical cancer treatment

Cervical cancer ranks third among the most prevalent deadly cancer in women worldwide and ranks first in developing countries. It is caused by human papilloma virus (HPV) infection. Thus HDACs have become prominent inhibition target for cervical cancer treatment. In order to discover the new alternative HDAC inhibitors (HDACIs), we conducted a computer-aided drug discovery and development (CADDD) based on de novo approach. The compound library is based on 4-[(2-oxo-1,3-thiazolidin-3-yl)carbonyl] aniline. Screening of the best drug leads was evaluated from several parameters, such as docking and interaction analysis, pharmacology, in silico preclinical trial and molecular dynamics analysis. The inhibitory activity of these new designed ligands against Homo sapiens class II HDAC was determined by molecular docking simulation. Docking analysis yielded eight best ligands which have better binding affinity than the standards. Therefore, interaction analysis indicated that all best ligands performed coordination with Zn2+ cofactor in HDAC charge-relay system which are essential for HDAC inhibitory activities of these inhibitors. Pharmacology analysis and preclinical trials of these compounds including pharmacology properties, bioactivity, mutagenicity-carcinogenicity, absorption, distribution, metabolism, excretion and toxicity (ADMET) properties were done through in silico methods. Through this analysis, the best ligands meet Lipinski’s rule of five, have a better drug score than standards, and show good bioactivities, oral bioavailability and ADMET properties. All best ligands also have good synthetic accessibility and were proved to be new compounds that have never been synthesized before. Stability of HDAC-ligand complexes was also calculated through molecular dynamics (MD) simulation. Based on this simulation, complex of the best ligands with corresponding HDAC has a good stability based on RMSD (root mean square deviation) and interaction analysis. The study thus reveals eight best ligands (F, Ib14, O38, Kb17, Gd40, Aa50, Gc42 and Bb38) which have better binding affinity against human class II histone deacetylase (HDAC) through molecular docking, dynamics and interaction analysis. The best ligands were also found to have good bioactivities, oral bioavailability and ADMET properties through in silico pharmacology analysis and preclinical trial. These compounds were found to have a good synthetic accessibility; therefore they could be synthesized for further biological and clinical test. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

Electric Literature of 10097-02-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 10097-02-6 is helpful to your research.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is an experimental science, Safety of 2,2-Bis(hydroxymethyl)butyric acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4, belongs to thiazolidines compound. In a document, author is Chen, Hua.

Design, synthesis and immunomodulating activity of C-pseudonucleosides containing thiazolidin-4-one and phenyl connected by acetamide bond

Several novel C-pseudonucleosides containing thiazolidin-4-one and phenyl connected by acetamide bond were rationally designed and easily synthesized at room temperature by using the unprotected sugar aldehyde as the starting material. The effects of the compounds on Con A-induced T cell proliferation were evaluated at five concentrations of 5, 10, 25, 50, and 100 mu mol/L Interestingly, compounds 7a and 8a = 2, R = H) exhibited immunostimulating activities, while compounds 5a, 6a (n = 1, R = H) and 7b, 8b (n = 2, R = CH3) showed immunosuppressive activities. Another two compounds 5b and 6b (n = 1, R = CH3) had no immunomodulating activities. These initial biological results suggested that subtle structural changes to the phenyl and acetamide bond of C-pseudonucleosides could have a significant effect on T cell proliferation bias, although it was difficult to formulate a rigorous structure activity relationship based on the observed activities. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10097-02-6, in my other articles. Safety of 2,2-Bis(hydroxymethyl)butyric acid.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com