Can You Really Do Chemisty Experiments About Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2421-28-5, in my other articles. Safety of Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride, molecular formula is , belongs to thiazolidines compound. In a document, author is da Silva, Daniel Schuch, Safety of Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride.

In Vitro Effects of 2-{4-[Methylthio(methylsulfonyl)]phenyl}-3-substitutedthiazolidin-4-ones on the Acetylcholinesterase Activity in Rat Brain and Lymphocytes: Isoform Selectivity, Kinetic Analysis, and Molecular Docking

This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldehyde (1) and from 4-(methylsulfonyl)benzaldehyde (2) were capable of inhibiting the AChE activity in vitro. Three compounds, two with a propylpiperidine (1b and 2b) moiety and one with a 3-(diethylamino)propyl (1c) moiety showed IC50 values of 13.81 mu M, and 3.13 mu M (1b), 55.36 mu M and 44.33 mu M (1c) for cerebral cortex and hippocampus, respectively, and 3.11 mu M for both (2b). Enzyme kinetics revealed that the type of AChE inhibition was mixed. Compound 1b inhibited the G1 and G4 AChE isoforms, while compounds 1c and 2b selectively inhibited the G4 isoform. Molecular docking showed a possible three-dimensional fit into the enzyme. Our findings showed that these thiazolidin-4-ones, especially those containing the propylpiperidine core, have a potential cholinesterase inhibitory activity and can be considered good candidates for future Alzheimer’s therapy.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2421-28-5, in my other articles. Safety of Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com