Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 6117-80-2, Name is (Z)-But-2-ene-1,4-diol, molecular formula is C4H8O2. In an article, author is Wang, Xiwen,once mentioned of 6117-80-2, HPLC of Formula: C4H8O2.
Novel 1,3,5-triazine derivatives exert potent anti-cervical cancer effects by modulating Bax, Bcl2 and Caspases expression
This study aimed to develop novel 1,3,5-triazine derivatives as potent anti-cervical cancer agents. The compounds were synthesized in short steps with an excellent yield and characterized via various spectroscopic and analytical methods. A structure-activity relationship study suggested that electron-withdrawing substituents showed greater anticancer activity than electron-donating groups. Compound 7p (p-fluoro) showed the highest activity against cervical cancer cells. In a nude mouse xenograft model inoculated with HeLa cells, 7p showed dose-dependent inhibition of cervical tumour growth. Histopathological examination of excised tumour-bearing tissues showed that 7p improved the microstructure in a dose-dependent manner. Compound 7p also increased the proportions of HeLa cells in G0/G1 and S-phase and significantly decreased that of G2/M-phase. The effects of 7p on C-caspase-3, C-caspase-9, Bcl-2 and Bax expression in HeLa cells were also determined.
If you¡¯re interested in learning more about 6117-80-2. The above is the message from the blog manager. HPLC of Formula: C4H8O2.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com