Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride. In a document, author is Incerti, Matteo, introducing its new discovery. Quality Control of Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride.
4-Thiazolidinone Derivatives as MMP Inhibitors in Tissue Damage: Synthesis, Biological Evaluation and Docking Studies
Nine 2-(1,2-benzothiazol-3-yl)-N-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)propanamides combining a benzisothiazole and 4-thiazolidinone in one framework were designed and synthesized. The aim of the study was to verify their effectiveness to affect the inflammatory/oxidative process in which free oxygen and nitrite (ROS and RNS) radicals, inflammatory mediators, such as nuclear factor kappa B (NF-kappa B), and matrix metalloproteinases (MMPs) are involved. Docking studies of all the compounds were performed in order to explore their binding mode at the MMP-9 protein. An appreciable anti-inflammatory/potential wound healing effects of the tested compounds was highlighted. Derivative 23, bearing a 4-carboxyphenyl substituent at C2 of the 4-thiazolidinone ring, exhibited the highest activity, being able to inhibit MMP-9 at nanomolar level(IC50 = 40 nM).
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2421-28-5 help many people in the next few years. Quality Control of Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com