SDS of cas: 94-41-7. Recently I am researching about BIOLOGICAL EVALUATION; ANTIHYPERGLYCEMIC EVALUATION; PYRAZOLINE DERIVATIVES; ANTIOXIDANT; BEARING; DESIGN; CANCER; MOIETY; ANTIBACTERIAL; IMIDAZOLE, Saw an article supported by the National Funds (FCT/MEC, Fundacao para a Ciencia e Tecnologia/Ministerio da Educacao e Ciencia) [UID/QUI/50006/2013, UID/Multi/04423/2013, UID/QUI/00062/2019]; Portuguese NMR Network; Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000024]; M.E.S.R.S. (Ministere de l’Enseignement Supe rieur et de la Recherche Scientifique), Algeria; DGRST (Direction Generale de la Recherche Scientifique et Technologique), Algeria; European Union (FEDER under the Partnership Agreement PT2020). Published in FUTURE SCI LTD in LONDON ,Authors: Chouiter, MI; Boulebd, H; Pereira, DM; Valentao, P; Andrade, PB; Belfaitah, A; Silva, AMS. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone
Aim: There is a continuous and urgent need for new anticancer agents with novel structures and target selectivity. Methods & results: The anticancer activity of the prepared compounds was assessed against human lung (A549) and stomach (AGS) cancer cell lines and evaluated in the noncancer human lung fibroblast (MRC-5) cell line. 2-Pyrazolines were devoid of toxicity in all cell lines used, chalcones bearing a beta-(benz)imidazole moiety being toxic toward AGS cell line. Mechanistic studies showed that these compounds trigger loss of cell viability and mitochondrial membrane potential, while eliciting morphological traits compatible with regulated cell death, which was ultimately shown to derive from caspase activation, specifically caspase-3. Conclusion: Chalcones 1-3 have been identified as new and promising anticancer agents toward the AGS cell line.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com