Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of 1-Isopropyl-4-methylcyclohexa-1,3-diene99-86-5, Name is 1-Isopropyl-4-methylcyclohexa-1,3-diene, SMILES is CC(C)C1=CC=C(C)CC1, belongs to thiazolidines compound. In a article, author is Bilgicli, Hayriye Genc, introduce new discover of the category.
Synthesis, characterization, biological evaluation, and molecular docking studies of some piperonyl-based 4-thiazolidinone derivatives
Heterocyclic compounds are of particular importance among pharmacologically active compounds. In this study, some piperonyl-based 4-thiazolidinone derivatives (2a-i) were synthesized and characterized by spectroscopic assays. All molecules were tested as enzyme inhibitory factors. These compounds were effective inhibitors of the enzymes acetylcholinesterase (AChE), alpha-glycosidase (alpha-Gly), and the human carbonic anhydrase I and II isoforms (hCA I and II), with K-i values in the range of 8.90-66.51 nM for alpha-Gly, 94.8-289.5 nM for hCA I, 106.3-304.6 nM for hCA II, and 0.55-2.36 nM for AChE. The synthesized molecules were also studied theoretically. Molecular docking calculations were performed to investigate the interaction between the target protein and molecules. CA inhibitor compounds have been clinically used for almost 60 years as antiglaucoma and diuretic drugs. The inhibition of the AChE enzyme results in the blockage of ACh hydrolysis. On the contrary, the design of inhibitor compounds or/and modulators for AChE is of major interest as it is one of the most popular tools to prevent Alzheimer’s disease.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 99-86-5. Application In Synthesis of 1-Isopropyl-4-methylcyclohexa-1,3-diene.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com