Related Products of 99-86-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 99-86-5, Name is 1-Isopropyl-4-methylcyclohexa-1,3-diene, SMILES is CC(C)C1=CC=C(C)CC1, belongs to thiazolidines compound. In a article, author is Kumar, Parvin, introduce new discover of the category.
Synthesis of novel inhibitors of alpha-amylase based on the thiazolidine-4-one skeleton containing a pyrazole moiety and their configurational studies
Postprandial hyperglycemia can be controlled by delaying the absorption of glucose resulting from carbohydrate digestion. alpha-Amylase is the initiator of the hydrolysis of polysaccharides, and therefore developing alpha-amylase inhibitors can lead to development of new treatments for metabolic disorders like diabetes mellitus. In the present work, we set out to rationally develop alpha-amylase inhibitors based on the thiazolidine-4-one scaffold. The structures of all these newly synthesized hybrids were confirmed by spectroscopic analysis (IR, H-1-NMR, MS). The appearance of two sets of signals for some protons in H-1 NMR revealed the existence of a mixture of 2E, 5Z (37.1-42.0%) and 2Z, 5Z isomers (58.4-62.8%), which was further supported by DFT studies. All the newly synthesized compounds have potential inhibitory properties as revealed through in vitro alpha-amylase inhibition activity. Compound 5a at 100 mu g mL(-1) concentration showed a remarkable inhibition of 90.04%. In vitro alpha-amylase inhibition was further supported by docking studies of compound 5a against the active site of human pancreatic alpha-amylase (PDB ID: 2QV4). The docking studies revealed that the bonding interactions found between 5a and human pancreatic alpha-amylase are similar to those responsible for alpha-amylase inhibition by acarbose.
Related Products of 99-86-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 99-86-5.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com