Optimization of troglitazone derivatives as potent anti-proliferative agents: Towards more active and less toxic compounds was written by Bordessa, Andrea;Colin-Cassin, Christelle;Grillier-Vuissoz, Isabelle;Kuntz, Sandra;Mazerbourg, Sabine;Husson, Gauthier;Vo, Myriam;Flament, Stephane;Martin, Helene;Chapleur, Yves;Boisbrun, Michel. And the article was included in European Journal of Medicinal Chemistry in 2014.Formula: C4H5NO2S This article mentions the following:
Δ2-Troglitazone derivatives were shown to exhibit anti-proliferative activity in a PPARγ-independent manner. We prepared various compounds in order to increase their potency and decrease their toxicity towards non-malignant primary cultured hepatocytes. Many compounds induced viabilities less than 20% at 10 μM on various cancer cell lines. Furthermore, five of them showed hepatocyte viability of 80% or more at 200 μM. In addition, compounds 17 and 18 exhibited promising maximum tolerated doses on a murine model, enabling future investigations. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Formula: C4H5NO2S).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Formula: C4H5NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com