In an article, author is Becka, Michal, once mentioned the application of 1823-59-2, Quality Control of 5,5′-Oxybis(isobenzofuran-1,3-dione), Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), molecular formula is C16H6O7, molecular weight is 310.22, MDL number is MFCD00039144, category is thiazolidines. Now introduce a scientific discovery about this category.
Synthesis and isomerization of acridine substituted 1,3-thiazolidin-4-ones and 4-oxo-1,3-thiazolidin-5-ylidene acetates. An experimental and computational study
Acridine thiosemicarbazones 3a-g, obtained through a two-step reaction between aromatic iso-thiocyanates and hydrazine followed by the treatment with acridin-9-carbaldehyde, in reaction with bifunctional reagents; methyl bromoacetate (MBA) and diethyl acetylenedicarboxylate (DEAD) afforded acridin-thiazolidinone derivatives 4a-g and 7a-f and not their regioisomers 6a-g and 9a-f. Derivatives 4a-g and 7a-f exhibit Z(C2N6)E(N7c8) configuration. Upon standing in DMSO-d(6) the thiazolidinones 4a-g and 7a-f spontaneously isomerized into Z(C2N6)Z(N7C8) isomers 5a-g and 8a-f to give a mixture of the both stereoisomers. All compounds were fully characterized by multinuclear NMR, mass spectrometry (MS) and X-ray crystal structure of 4b is also described. X-ray diffraction study revealed that the representative compound 4b crystallized in the monoclinic crystal system with the C2/c space group and Z = 4. Intramolecular C1′-H1′ center dot center dot center dot N-7 hydrogen bond between the acridine proton H-1′ and nitrogen N-7 of linker existed. This hydrogen bond is responsible for the E isomerism on C-8 atom which was observed in the NMR experiments. Quantum-chemical calculations and NOESY experiments confirmed Z(C2N6)Z(N7C8) configuration of the transformed stereoisomers 5a-g and 8a-f. (C) 2017 Elsevier B.V. All rights reserved.
If you are interested in 1823-59-2, you can contact me at any time and look forward to more communication. Quality Control of 5,5′-Oxybis(isobenzofuran-1,3-dione).
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com