Electric Literature of 26364-65-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 26364-65-8, Name is 2-Cyanoimino-1,3-thiazolidine,introducing its new discovery.
NEW SYNTHESES OF 2-CYANO-1-METHYL-3-<2-<<(5-METHYL-1H-IMIDAZOL-4-YL)METHYL>THIO>ETHYL>GUANIDINE (CIMETIDINE)
A new synthesis of 2-cyano-1-methyl-3-<2-<<(5-methyl-1-H-imidazol-4-yl)methyl>thio>ethyl>guanidine, 6 (cimetidine) utilizing the aziridine derivative 5 as a two-carbon one-nitrogen synthon, is reported.Attempts to prepare the key intermediate 5 via aziridine forming ring closure of 18, as well as attempted insertion of aziridine into the carbon-sulphur bond in 11 or 12 are described.Low yields of 6 were obtained both on insertion of aziridine within 12, and on alkylation of 14 with 8, followed by decomposition of the sulphonium salt 15.Formation of 5 from 2 and aziridine in the presence of Ag(I) ions is found to follow predominantly an elimination-addition mechanism, via the highly unstable carbodiimide 4, rather than direct substitution.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 26364-65-8, and how the biochemistry of the body works.Electric Literature of 26364-65-8
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Quinuclidine – Wikipedia,
Quinuclidine | C7H634N | ChemSpider