The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: C5H8O4, 108-59-8, Name is Dimethylmalonate, SMILES is O=C(OC)CC(OC)=O, in an article , author is Rani, Neeru, once mentioned of 108-59-8.
Synthesis, Antimicrobial, and Molecular Docking Studies of 1,3-Thiazolidin-4-one Analogs Bearing Benzothiazole
The title compounds, 3-(7-substituted-6-fluoro-1,3-benzothiazole-2-yl)-2-(4-hydroxy-2-methoxy phenyl)-1,3-thiazolidine-4-ones (5a-k), were prepared by the reaction of 3-(7-chloro-6-fluoro-1,3-benzothiazole-2-yl)- 2-(4-hydroxy-2-methoxyphenyl)-1,3-thiazolidine-4-one (4) with substituted aromatic amines in dry dimethylformamide (DMF). The synthesized compounds were evaluated for their antimicrobial activity against bacterial (Gram positive, and Gram negative) and fungal strains. Compounds 5a-c, 5e, 5g, 5h, and 5k were found to be most active against various bacterial strains and compounds 5b and 5d against antifungal strains at very low concentration. In the docking study, the target protein (CYP450 3A4) was used against synthesized compounds. Among the titled compounds, 5b was found to be most potent and have a high docking score of -8.634 as compared to Ketoconazole (-6.55 as Dock Score).
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 108-59-8, you can contact me at any time and look forward to more communication. COA of Formula: C5H8O4.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com