Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, ACS Medicinal Chemistry Letters called Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity, Author is Grenier, Melissa C.; Ding, Shilei; Vezina, Dani; Chapleau, Jean-Philippe; Tolbert, William D.; Sherburn, Rebekah; Schon, Arne; Somisetti, Sambasivarao; Abrams, Cameron F.; Pazgier, Marzena; Finzi, Andres; Smith, Amos B., which mentions a compound: 114527-53-6, SMILESS is OC(=O)C1CNC2=CC=CC=C2C1, Molecular C10H11NO2, Application In Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid.
With approx. 37 million people living with HIV worldwide and an estimated 2 million new infections reported each year, the need to derive novel strategies aimed at eradicating HIV-1 infection remains a critical worldwide challenge. One potential strategy would involve eliminating infected cells via antibody-dependent cellular cytotoxicity (ADCC). HIV-1 has evolved sophisticated mechanisms to conceal epitopes located in its envelope glycoprotein (Env) that are recognized by ADCC-mediating antibodies present in sera from HIV-1 infected individuals. Our aim is to circumvent this evasion via the development of small mols. that expose relevant anti-Env epitopes and sensitize HIV-1 infected cells to ADCC. Rapid elaboration of an initial screening hit using parallel synthesis and structure-based optimization has led to the development of potent small mols. that elicit this humoral response. Efforts to increase the ADCC activity of this class of small mols. with the aim of increasing their therapeutic potential was based on our recent cocrystal structures with gp120 core.
In addition to the literature in the link below, there is a lot of literature about this compound(1,2,3,4-Tetrahydroquinoline-3-carboxylic acid)Application In Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, illustrating the importance and wide applicability of this compound(114527-53-6).
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com