So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Monti, Donato; Sleiter, Giancarlo researched the compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ).Category: thiazolidine.They published the article 《Electrophilic heteroaromatic substitutions. XI. Thallium in pyrrole chemistry. Formation of C-pyrrylthallium derivatives》 about this compound( cas:2199-44-2 ) in Gazzetta Chimica Italiana. Keywords: pyrrole thallation substituent effect; pyrrylthallium derivative. We’ll tell you more about this compound (cas:2199-44-2).
Reaction of several pyrrole derivatives with Tl(III) salts was investigated under different exptl. conditions. C-Thallation is dependent on what position (α or β) of the pyrrole nucleus is amenable to attack, and on the nature of the thallating agent. Yields are strongly influenced by electronic and steric effects of the substituents already present in the pyrrole nucleus and by the nature of the reaction medium. Spectroscopic and anal. data for the C-pyrrylthallium derivatives prepared are reported. E.g., treating pyrroles I (R = H; R1 = Me, Et) with Tl(OAc)3 in MeCN or CH2ClCH2Cl gave 37-79% I [R = (AcO)2Tl; same R1].
In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate)Category: thiazolidine, illustrating the importance and wide applicability of this compound(2199-44-2).
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com