Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of Tris(2-chloroethyl) phosphate115-96-8, Name is Tris(2-chloroethyl) phosphate, SMILES is O=P(OCCCl)(OCCCl)OCCCl, belongs to thiazolidines compound. In a article, author is Souza, Silvana P., introduce new discover of the category.
Antimicrobial and Cytotoxicity Activities of 2-(aryl)-3-(benzo[d][1,3] dioxol-5-yl) thiazolidin-4-ones
Background: This study evaluated the biological properties of twelve 1,3-thiazolidin-4ones by assessing antifungal and antibacterial activities. Methods: All compounds were tested against three fungi and two bacteria. The lowest concentration that produced a >= 50% inhibition of the growth of yeast in comparison with positive control was identified as MIC50. Compound 1b showed the best antifungal result against Candida albicans with MIC50 100 mu g/ml (52.38% of growth inhibition). In the antifungal Rhodotorula assay, two compounds showed good antifungal activity with MIC50 100 mu g/ml (1f: 82.91% and 1i: 61.91%). For C. parapsilosis compound 1i has MIC50 200 mu g/ml. Results and Conclusion: No antibacterial activity was found for Staphylococcus aureus and Escherichia coli at the highest concentration tested (400 mu g/ml). The cytotoxicity study for three compounds was carried out against primary astrocyte cells and no toxic effect was found at 400 mu M. This study discovered at least two potential compounds that will guide further chemical modification to search for better results.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 115-96-8. Application In Synthesis of Tris(2-chloroethyl) phosphate.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com