The thiazolidine compound, cas is 179087-93-5 name is 2-(4-((2,4-Dioxothiazolidin-5-yl)methyl)phenoxy)acetic acid, mainly used in chemical industry, its synthesis route is as follows.
Examples (Example 1) 4-[(2,4-Dioxothiazolidin-5-yl)methyl]phenoxyacetyl chloride Thionyl chloride (170 mg, 1.34 mmol) and then pyridine (1 drop) were added to a suspension of 4-[(2,4-dioxothiazolidin-5-yl)methyl]phenoxyacetic acid (220 mg, 0.78 mmol) in dichloromethane (10 ml) at room temperature, and the mixture was refluxed for 3.5 hours. The resulting solution was concentrated under reduced pressure to obtain about 250 mg of the gummy target compound. Nuclear magnetic resonance spectrum (400 MHz, DMSO-d6) delta (ppm): 3.05 (1H, dd, J = 9.0 Hz, J = 14.1 Hz, CH2CH), 3.31 (1H, dd, J = 4.1 Hz, J = 14.1 Hz, CH2CH), 4.64 (2H, s, CH2O), 4.87 (1H, dd, J = 4.1 Hz, J = 9.0 Hz, CH2CH), 6.85 (2H, d, J = 8.6 Hz, aromatic), 7.16 (2H, J = 8.6 Hz, aromatic), 12.02 (1H, s, NH).
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Reference£º
Patent; Daiichi Sankyo Company, Limited; EP1894929; (2008); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com