With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5908-62-3,1,1-Dioxo-isothiazolidine,as a common compound, the synthetic route is as follows.,5908-62-3
PREPARATION 1 STR61 A mixture of 4-isopropenyl pyridine (1.79 g) and isothiazolidine-1,1-dioxide (1.81 g) was heated at 130 C. during the addition of “Triton B” (Trade Mark, trimethylbenzylammonium hydroxide) (0.25 g added every hour for four hours; 40% solution in water). After stirring for 16 hours at 130 the mixture was cooled and taken in chloroform (50 cm3) and water (50 cm3). The aqueous phase was extracted with chloroform (3*20 cm3) and the dried (MgSO4) extracts were evaporated to given an oil. Chromatography on silica (“Merck 60. 9385”) eluding with ethyl acetate gave 2-[2-(4-pyridyl)prop-1-yl]isothiazolidine-1,1-dioxide which crystallized from ethyl acetate-hexane as needles, m.p. 90-92 (1.01 g). Analysis %: Found: C,55.0; H,6.8; N,12.0. Calculated for C11 H16 N2 O2 S: C,55.0; H,6.7; N,11.7.
5908-62-3 1,1-Dioxo-isothiazolidine 642157, athiazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; Pfizer Inc.; US4489075; (1984); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com