With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2682-49-7,Thiazolidin-2-one,as a common compound, the synthetic route is as follows.
b. (N’,N’-Dimethyl-3-aminopropyl)-2-thiazolidinone To a solution of 2-thiazolidinone (4.15 g, 40.18 mmol) in acetonitrile (60 ml) were added potassium carbonate (13.3 g 96.2 mmol), N,N-dimethyl-3-aminopropyl chloride hydrochloride (7.63 g, 48.3 mmol), and 18-crown-6 (catalytic amount). The mixture was refluxed for 18 hours, solvent removed in vacuo, then redissolved in dichloromethane and 1 M potassium chloride (40 ml each). The aqueous phase was isolated and extracted twice with 30 ml portions of dichloromethane. The combined organic fraction was washed with saturated sodium chloride (~50 ml), dried over sodium sulfate, filtered, and dried in vacuo.
2682-49-7, 2682-49-7 Thiazolidin-2-one 97431, athiazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; University of Utah; US6340746; (2002); B1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com