With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19771-63-2,(R)-2-Oxothiazolidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
EXAMPLE 17 (4R)-N-[1-(Nitrooxymethyl)ethyl]-2-oxothiazolidine-4-carboxamide (Compound No. 1-30) A procedure similar to that described in Example 1 was repeated, but using 1.5 g of (4R)-2-oxothiazolidine-4-carboxylic acid and 2.3 g of 1-(nitrooxymethyl)ethylamine nitrate, to obtain 0.35 g of the title compound as colorless crystals, melting at 112-114 C. (after recrystallization from ethanol). Nuclear Magnetic Resonance Spectrum (CDCl3 +hexadeuterated dimethyl sulfoxide) delta ppm: 1.27 (3H, doublet, J=7 Hz); 3.68 (2H, doublet, J=7 Hz);
19771-63-2 (R)-2-Oxothiazolidine-4-carboxylic acid 72390, athiazolidine compound, is more and more widely used in various.
Reference£º
Patent; Sankyo Company, Limited; US5298516; (1994); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com