As a common heterocyclic compound, it belong thiazolidine compound,(S)-4-Phenylthiazolidine-2-thione,185137-29-5,Molecular formula: C9H9NS2,mainly used in chemical industry, its synthesis route is as follows.,185137-29-5
General procedure: To a mixture of N-crotonyl oxazolidinone 7 (100 mg, 0.43 mmol) and 4-phenyl-2-oxazolidine-2-thione 4 (77.1 mg, 0.43 mmol) in dichloromethane (5.0 mL) was added triethylamine (131.2 mg, 1.29 mmol) at room temperature. The resulting mixture was stirred and heated to reflux overnight. After cooling to room temperature, water (10 mL) was added and the reaction mixture was extracted with CH2Cl2 (3 x 7 mL) The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford crude Michael addition product. The crude residue was purified by silica gel flash column chromatography.
With the synthetic route has been constantly updated, we look forward to future research findings about (S)-4-Phenylthiazolidine-2-thione,belong thiazolidine compound
Reference£º
Article; Munive, Laura; Dzakuma, Sena A.; Olivo, Horacio F.; Tetrahedron Letters; vol. 54; 10; (2013); p. 1230 – 1232;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com