With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.171877-39-7,(S)-4-Benzylthiazolidine-2-thione,as a common compound, the synthetic route is as follows.
A solution cooled in an ice bath of (S)-4-benzylthiazolidin-2-thione (18.37g, 87.87mmol) in CH2Cl2 (266mL) was treated with Et3N (2 eq) and then with 4-phenylbutanoyl chloride (Intermediate XI.1, 114.23mmol). The resulting mixture was stirred at room temperature for 12 days and then quenched with brine and extracted with CH2Cl2, dried with Na2SO4, filtered and concentrated. Purification by silica gel chromatography using Hex:AcOEt mixtures of increasing polarity (95:5, 9:1, 8:2, 7:3 and 6:4) afforded 24g (70%) of a yellow oil. 13C-NMR (500MHz, CDCl3) delta 201.06, 173.73, 141.53, 136.56, 129.44, 128.88, 128.53, 128.36, 127.19, 125.96, 68.53, 37.93, 36.79, 35.11, 31.90, 26.43.
171877-39-7 (S)-4-Benzylthiazolidine-2-thione 11458470, athiazolidine compound, is more and more widely used in various.
Reference£º
Patent; Universitat Jaume I; EP2168954; (2010); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com