As a common heterocyclic compound, it belong thiazolidine compound,3-Aminorhodanine,1438-16-0,Molecular formula: C3H4N2OS2,mainly used in chemical industry, its synthesis route is as follows.,1438-16-0
To a solution of isatin (1, 100.0 mg, 0.68 mmol) in ethanol (10 mL)was added slowly to the solution of 3-amino-rhodanine (2, 100,7 mg,0.68 mmol) using dropwise. The reaction mixture was stirred forovernight at room temperature without catalyst, and was monitored byTLC. After the completion of the reaction, the red product formed wasrecrystallized from ethanol, filtered, and dried in vacuo. After recrystallization,3 (162 mg, 86%), which is E isomer, was obtained asdark yellow solid (m.p. > 300 C). 1H-NMR (400 MHz, DMSO-d6): delta11.34 (s, NH, 1 H), 8.68 (d, J =7.6 Hz, =CH, 1 H), 7.83 (d, J=7.6 Hz, =CH, 1 H), 7.62 (t, J =7.6 Hz, =CH, 1 H), 7.18 (t, J=7.6 Hz, =CH, 1 H), 4.22 (s, CH2, 2 H); 13C-NMR (100 MHz, DMSOd6):delta 193.4, 169.5, 165.0, 146.3, 134.7, 130.1, 129.3, 123.7, 121.9,34.2 (Fig. S3).
With the synthetic route has been constantly updated, we look forward to future research findings about 3-Aminorhodanine,belong thiazolidine compound
Reference£º
Article; Bayindir, Sinan; Journal of Photochemistry and Photobiology A: Chemistry; vol. 372; (2019); p. 235 – 244;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com