2-Aminothiazolin-4-one and 2-iminothiazolidin-4-one derivatives. I. The reaction of chloroacetic acid with N-monoalkylthiourea was written by Akerblom, Eva. And the article was included in Acta Chemica Scandinavica (1947-1973) in 1967.COA of Formula: C4H5NO2S This article mentions the following:
The reaction of ClCH2CO2H with N-alkylthioureas in the presence of NaOAc gave II. The same reaction performed in the absence of a base gave varying results depending on the size of the alkyl substituent. Thus, with N-methylthiourea, I (R = Me) was obtained. With N-ethyl- and N-propylthiourea, the corresponding I and II were both obtained in the proportions 3-4:1. The reaction with N-isopropylthiourea gave exclusively II (R = iso-Pr) (III). In acidic media, the 2-alkylamino compounds (II) rearranged to the 3-alkyl compounds I while under alk. conditions the reaction was reversed. III did not rearrange. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3COA of Formula: C4H5NO2S).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.COA of Formula: C4H5NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com