Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C4H4O2, 922-67-8, Name is Methyl propiolate, SMILES is C#CC(OC)=O, belongs to thiazolidines compound. In a document, author is Krajnakova, Lucia, introduce the new discover.
Intracellular distribution of new tacrine analogues as a potential cause of their cytotoxicity against human neuroblastoma cells SH-SY5Y
Four new glyco-conjugated tacrine derivatives, 4-(2,3,4,6-tetra-O-acetyl–D-glucopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (1), 4-(2,3,4,6-tetra-O-acetyl–D-mannopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (2), 2-(1,2,3,4-tetrahydroacridin-9-yl)hydrazono-3-(2,3,4,6-tetra-O-acetyl–D-galactopyranosyl)-1,3-thiazolidin-4-one (3) and [2-(1,2,3,4-tetrahydro-acridin-9-yl)hydrazono-3-(2,3,4,6-tetra-O-acetyl–D-glucopyranosyl)-4-oxothiazolidin-5-yliden]acetate (4) were synthesized and their characteristics were investigated. All of the novel derivatives were found to inhibit acetylcholinesterase obtained from Electrophorus electricus at a magnitude of one order less than that of the control tacrine. Derivatives 1-3 were found to be nontoxic towards human neuroblastoma SH-SY5Y cells, while compound 4 was markedly cytotoxic against these cells (IC50 value 2 mu M, 72h). These differences in cytotoxicity were examined further by investigating the uptake and intracellular localization of the tacrine derivatives. Non-cytotoxic derivatives 1-3 were found to localize outside of the nuclei, showing a marked preference for the lysosomes and the mitochondria; in contrast, the cytotoxic derivative 4 was localized in the nuclei of the neuroblastoma cells. Interaction studies revealed that derivative 4 displays a high affinity towards DNA, and also provided evidence of the compound’s ability to inhibit Topo I.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 922-67-8. Computed Properties of C4H4O2.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com