Related Products of 6117-80-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 6117-80-2, Name is (Z)-But-2-ene-1,4-diol, SMILES is OC/C=CCO, belongs to thiazolidines compound. In a article, author is Lu, Min, introduce new discover of the category.
Design and development of novel thiazolidin-4-one-1,3,5-triazine derivatives as neuro-protective agent against cerebral ischemiareperfusion injury in mice via attenuation of NF-kappa B
The present study enumerates the discovery and development of novel thiazolidin-4-one-1,3,5-triazine as neuro-protective agent against cerebral ischemia-reperfusion injury in mice. These compounds showed significant inhibition of NF-kappa B transcriptional activity in LPS-stimulated RAW264.7 cells, displaying compound8kas most potent inhibitor among the tested derivative. The compound 8k was further studied in in vivo middle cerebral artery occlusion (MCAO) mice model for neuro-protective action. Results suggest that compound8kcauses attenuation of inflammation (TNF-alpha, IL-beta, and IL-6), oxidative stress (SOD, GSH, and MDA), and apoptosis (Bcl-2, Bax, and cleaved caspase-3) in MCAO mice in concentration-dependent manner. Collectively, our results documented that compound8kpre-treatment protects cerebral I/R. This novel lead scaffold may be helpful for investigation of new neuro-protective agent by inactivation of NF-kappa B.
Related Products of 6117-80-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6117-80-2.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com