One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Thiazolidin-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 2682-49-7, Name is Thiazolidin-2-one, molecular formula is C3H5NOS
Synthesis and evaluation of anticonvulsant activities of 5-benzylidene-2-(5-methylisoxazol-3-ylimino)thiazolidin-4-one derivatives
Fifteen new 5-benzylidene-2-(5-methylisoxazol-3-ylimino)thiazolidin-4-one derivatives (4-18) were synthesized and evaluated for their preliminary anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES) and rotarod tests. The structures of synthesized compounds were established by IR,1H NMR,13C NMR and mass spectral data. Among the compounds studied, 5-(3-fluorobenzylidene)-2-(5-methylisoxazol-3-ylimino)thiazolidin-4-one (8) was the most potent compound, with a median effective dose of 43.9 mg/kg and a high protective index (PI) of more than 11.1 after intraperitoneal administration in mice. Compound 8 showed significant oral activity against MES-induced seizures in mice, with an ED50 of 84.2 mg/kg and a PI above 11.8. These results demonstrate that compound 8 is safer than the commercially drugs.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Thiazolidin-2-one, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2682-49-7
Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H478N | ChemSpider