Related Products of 19771-63-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 19771-63-2, (R)-2-Oxothiazolidine-4-carboxylic acid, introducing its new discovery.
The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass
The ubiquitin?proteasome system (UPS) is the main regulatory mechanism of protein degradation in skeletal muscle. The ubiquitin-ligase enzymes (E3s) have a central role in determining the selectivity and specificity of the UPS. Since their identification in 2001, the muscle specific E3s, muscle RING finger-1 (MuRF-1) and muscle atrophy F-box (MAFbx), have been shown to be implicated in the regulation of skeletal muscle atrophy in various pathological and physiological conditions. This review aims to explore the involvement of MuRF-1 and MAFbx in catabolism of skeletal muscle during various pathologies, such as cancer cachexia, sarcopenia of aging, chronic kidney disease (CKD), diabetes, and chronic obstructive pulmonary disease (COPD). In addition, the effects of various lifestyle and modifiable factors (e.g. nutrition, exercise, cigarette smoking, and alcohol) on MuRF-1 and MAFbx regulation will be discussed. Finally, evidence of potential strategies to protect against skeletal muscle wasting through inhibition of MuRF-1 and MAFbx expression will be explored.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Related Products of 19771-63-2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about Related Products of 19771-63-2
Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H691N | ChemSpider