Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates) was written by Lalezari, Iraj;Schwartz, Edward L.. And the article was included in Journal of Medicinal Chemistry in 1988.Quality Control of Thiazolidine-2-carboxylic acid This article mentions the following:
A series of title compounds I (R = Ph, 4-FC6H4, 4-ClC6H4, 3,4-Cl2C6H3, X = S), the 1-thia analogs of I (R = 3,4-Cl2C6H3, X = CH2) (II) were prepared by multistep syntheses from thiazolidine-2-carboxylic acid. The compounds were tested for growth inhibitory activity with the HL-60 human promyelocytic leukemia cell line. Three of the compounds had antileukemic activity equal to that of II, while I (R = 4-ClC6H4, X = S) was approx. 75% more potent. A simple aromatic derivative, 1,2-(Me2CHNHCO2CH2)2C6H4 had no activity in this system. Antitumor activity was also tested in a colony formation assay with HT-29 human colon carcinoma cells. I reduced relative cell survival by over 3 logs at a concentration of 300 μM (2-h exposure), while a comparable inhibition was observed with 150 μM II. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Quality Control of Thiazolidine-2-carboxylic acid).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Quality Control of Thiazolidine-2-carboxylic acid
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com