Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Recommanded Product: 16310-13-7
Thiazolidine-2-carboxylic acid, an adduct of cysteamine and glyoxylate, as a substrate for D-amino acid oxidase was written by Fitzpatrick, Paul F.;Massey, Vincent. And the article was included in Journal of Biological Chemistry in 1982.Recommanded Product: 16310-13-7 This article mentions the following:
A mixture of cysteamine and glyoxylate, proposed by G. A. Hamilton, et al. (1979) to form the physiol. substrate of hog kidney D-amino acid oxidase (I), was confirmed to act as a good substrate for the pure enzyme. As proposed by those workers, it was shown that the actual substrate is thiazolidine-2-carboxylic acid (II), formed from cysteamine and glyoxylate with a 2nd-order rate constant of 84 min-1 M-1 at 37°, pH 7.5. Steady state kinetic anal. revealed that II was a better substrate at pH 8.5 than at pH 7.5. At both pH values, the catalytic turnover number was similar to that obtained with D-proline. I was rapidly reduced by II to form a reduced enzyme-imino acid complex, as is typical with I substrates. The product of oxidation was shown by NMR to be Δ2-thiazoline-2-carboxylic acid. Racemic II was completely oxidized by I. The directly measured rate of isomerization of L–II to the D-isomer was compared to the rate of oxidation of the L-isomer by I. Their identity over the temperature range 2-30° established that the apparent activity with the L-amino acid can be explained quant. by the rapid, prior isomerization to D–II. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Recommanded Product: 16310-13-7).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Recommanded Product: 16310-13-7
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com