Stereoselective and Catalytic Synthesis of anti-β-Alkoxy-α-azido Carboxylic Derivatives was written by Fernandez-Valparis, Javier;Romea, Pedro;Urpi, Felix;Font-Bardia, Merce. And the article was included in Organic Letters in 2017.Recommanded Product: 76186-04-4 This article mentions the following:
Nonracemic azidoacetyl thiazolidinethione I was prepared; in the presence of NiCl2(PMe3)2, I underwent diastereoselective condensation reactions with aryl aldehyde acetals RCH(OR1)2 (R = 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 1,3-benzodioxol-5-yl, 4-Me2NC6H4, 4-MeC6H4, Ph, 4-ClC6H4; R1 = Me, H2C:CHCH2, PhCH2) and alkynyl dicobalt hexacarbonyl complexes mediated by Et3SiOTf and 2,6-lutidine in CH2Cl2 to yield nonracemic β-alkoxy-β-aryl-α-azidopropanoyl thiazolidinethiones such as II (R = 4-MeOC6H4, 3-MeOC6H4, 2-MeOC6H4, 1,3-benzodioxol-5-yl, 4-Me2NC6H4, 4-MeC6H4, Ph, 4-ClC6H4; R1 = Me, H2C:CHCH2, PhCH2) and dicobalt hexacarbonyl β-alkoxy-α-azidobutynoyl thiazolidinethiones in 15-85% yields (three of eighteen examples < 50% yields) and in 60:40->97:3 dr (three of eighteen examples < 80:20 dr). In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Recommanded Product: 76186-04-4).
(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Recommanded Product: 76186-04-4
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com