N-(β-Mercapto)arylamines in the synthesis of 2-acyl-3- arylthiazolidines and 3-arylthiazolidine-2-carbonic acids was written by Yur’ev, Yu. K.;Dyatlovitskaya, S. V.. And the article was included in Khimicheskaya Nauka i Promyshlennost in 1957.Application In Synthesis of Thiazolidine-2-carboxylic acid This article mentions the following:
Heating 0.01 mole N-(β-mercaptoethyl)aniline (I) with 0.03 mole methylglyoxal (II) in 8 ml. EtOH and decomposing with ice gave 96% 2-acetyl-3-phenylthiazolidine, m. 57.5-8° (80% EtOH). The 2-Bz derivative was obtained in 100% yield by treating with 0.04 mole phenylglyoxal instead of with II. A mixture of 0.5 mole I, 0.09 mole CHCl2CO2H, 0.09 mole anhydrous AcONa, and 0.1 mole Na2CO3 in 50 ml. absolute EtOH boiled 4 hrs., the EtOH distilled, and the residue treated with N HCl and EtOH yielded 50% 3-phenylthiazolidine-2-carboxylic acid; amide, m. 171-2° (decomposition) (EtOH); Et ester, b2 163-4°; hydrazide, m. 135-6° (H2O). In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application In Synthesis of Thiazolidine-2-carboxylic acid).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Application In Synthesis of Thiazolidine-2-carboxylic acid
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com