Endogenous alkaloids in man. XI. Analysis of glyoxylate-derived 1,3-thiazolidines by ion-pair-assisted reversed-phase chromatography was written by Bringmann, Gerhard;Hesselmann, Christiana;Feineis, Doris. And the article was included in Journal of Chromatography in 1992.Electric Literature of C4H7NO2S This article mentions the following:
Reversed-phase ion-pair chromatog., using cetyltrimethyl ammonium hydrogen sulfate as detergent was applied to the anal. of the highly polar glyoxylate-derived 1,3-thiazolidines. On the base of this, HPLC graphic separation of diastereomeric compounds was achieved. Removal of the hydrophobic counterion by precipitation as its insoluble iodide, followed by an extraction with chloroform, seems to be a promising first step to establish ion-pair-assisted chromatog. as a preparative HPLC method for the isolation of polar compounds In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Electric Literature of C4H7NO2S).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Electric Literature of C4H7NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com