Endogenous alkaloids in man. XXI. Analysis of glyoxylate-derived 1,3-thiazolidines and their precursors after trimethylsilylation by gas chromatography-mass spectrometry was written by Bringmann, Gerhard;Hesselmann, Christiana;Feineis, Doris. And the article was included in Journal of Chromatography A in 1995.Application of 16310-13-7 This article mentions the following:
A gas chromatog. procedure was developed for the simultaneous anal. of glyoxylate-derived 1,3-thiazolidines and their precursors, such as L-cysteine, cysteamine, and D-(-)-penicillamine as well as the toxic glyoxylic acid. The assay involves conversion of these highly polar compounds to volatile trimethylsilyl (TMS) derivatives, chromatog. on a polar fused-silica capillary column, and determination using flame-ionization detection or electron-impact ionization mass spectrometry. On the basis of this anal. device, the resolution of the diastereomeric pairs of 1,3-thiazolidine-2,4-dicarboxylic acids was achieved. Based upon the observation that no epimerization occurs during the silylation procedure, for the first time a reliable method was established for the determination of the diastereomeric ratio of such alkaloid-type heterocycles on a trace scale. Furthermore, studies concerning thiazolidine formation under derivatization conditions in the presence of the precursors glyoxylic acid and D-(-)-penicillamine are described. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application of 16310-13-7).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Application of 16310-13-7
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com