Synthesis and quantum chemistry of (R) and (S)-N-cinnamyl-4-isopropylthiazolidine-2-thione was written by Li, Ye-Zhi;Guo, Chun-Xiao;Lu, Xiang-Yang;Zhao, Xiao-Gang;Huang, Hua-Min. And the article was included in Youji Huaxue in 1998.Related Products of 76186-04-4 This article mentions the following:
(R)-3-methyl-2-amino-Bu alc., [α]D20 = -15.18°C, (S)-3-methyl-2-amino-Bu alc., [α]D20 = +16.96°, were prepared by the reduction of D- or L-value Me ester in the presence of KBH4 and CaCl2. (R)-4-isopropylthiazolidine-2-thione, [α]D20 = +37.00° and (S)-4-isopropylthiazolidine-2-thione, [α]D20 = -36.90°, were obtained via cyclization by refluxing a solution of (R) or (S)-3-methyl-2-aminobutylalc. in CS2 and KOH. (R)-N-cinnamyl-4-iso-Pr thiaxolidine-2-thione, [α]D20 = -169.72° and (S)-N-cinnamyl-4-isopropylthiazolidine-2-thione, [α]D20 = +173.20°, were prepared by dehydro-chlorination between cinnamyl chloride and (R) or (S)-4-isopropylthiazolidine-2-thione in the presence of Et3N. The electronic structure of products and reactants were studied by MO PM3 method. The reaction enthalpies and optimized configuration for products were obtained. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Related Products of 76186-04-4).
(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Related Products of 76186-04-4
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com