Synthesis of the Anti-HIV Agent (-)-Hyperolactone C by Using Oxonium Ylide Formation-Rearrangement was written by Hodgson, David M.;Man, Stanislav. And the article was included in Chemistry – A European Journal in 2011.Safety of (S)-4-Isopropylthiazolidine-2-thione This article mentions the following:
Starting from readily available (S)-styrene oxide, an asym. synthesis is described of the naturally occurring anti-HIV spirolactone (-)-hyperolactone C (I), which possesses adjacent fully substituted stereocenters. The key step involves a stereocontrolled Rh(II)-catalyzed oxonium ylide formation-[2,3] sigmatropic rearrangement of an α-diazo-β-ketoester bearing allylic ether functionality. From the resulting furanone, an acid-catalyzed lactonization and dehydrogenation gives the natural product. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Safety of (S)-4-Isopropylthiazolidine-2-thione).
(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Safety of (S)-4-Isopropylthiazolidine-2-thione
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com