Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation was written by Kotha, Sambasivarao;Sreevani, Gaddamedi;Dzhemileva, Lilya U.;Yunusbaeva, Milyausha M.;Dzhemilev, Usein M.;D’yakonov, Vladimir A.. And the article was included in Beilstein Journal of Organic Chemistry in 2019.Computed Properties of C4H5NO2S This article mentions the following:
A new synthetic approach was reported to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chem. and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alc. derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Computed Properties of C4H5NO2S).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Computed Properties of C4H5NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com