2,4-Thiazolidinedione derivatives was written by Turkevich, N. M.;Yurzhenko, S. A.. And the article was included in Khim. Geterotsikl. Soedin., Sb. 3 in 1971.Synthetic Route of C4H5NO2S This article mentions the following:
Reaction of 2,4-thiazolidinedione (I) with KOH gave the K salt which with Me2SO4 or the appropriate halogen compound gave the following II (R and % yield given): Me, 65; Et, 46; CH2CO2Me, 62; Et2NCH2CH2, 46; PhCH2, 85; 2,4-(O2N)2C6H3, 30. Heating I K salt with an acyl chloride gave the following II (same data given): Bz, 64; p-O2NC6H4CO, 56; Ph2CHCO, 42; Ph2CClCO, 62. Reaction of I with p-O2NC6H4CHO gave 85% III (R = H), which with KOH, then RCl gave 76% III (R = PhCH2) (IV), and 69% III (R = Et2NCH2CH2). Refluxing IV with N2H4.H2O in alc. gave the azine. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Synthetic Route of C4H5NO2S).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Synthetic Route of C4H5NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com