Reaction of O-alkyl-N-substituted iminothiocarbonates with bromoacetyl bromide. A general method for the synthesis of 3-substituted 1,3-thiazolidine-2,4-diones was written by Imrich, Jan;Bernat, Juraj;Kristian, Pavol;Busova, Tatiana;Hocova, Slavka. And the article was included in Collection of Czechoslovak Chemical Communications in 1996.Application In Synthesis of 3-Methylthiazolidine-2,4-dione This article mentions the following:
Reaction of O-methyl-N-substituted iminothiocarbonate sodium salts RN:C(OMe)SNa [R = (substituted) 9-acridinyl, Me, (substituted) Ph, 1-naphthyl, 1-naphthylmethyl] with bromoacetyl bromide represents a new general method for preparation of 3-substituted 1,3-thiazolidine-2,4-diones I in good yields and high purity. The structure of the synthesized products has been confirmed by 1H NMR, 13C NMR, IR, and mass spectroscopy as well as by independent synthesis. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Application In Synthesis of 3-Methylthiazolidine-2,4-dione).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Application In Synthesis of 3-Methylthiazolidine-2,4-dione
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com