Synthesis of 3-substituted-2,4-dioxothiazolidine derivatives from 1-substituted-4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thiones was written by Singh, Harjit;Singh, Paramjit;Deep, Kanwal. And the article was included in Chemistry & Industry (London, United Kingdom) in 1981.Recommanded Product: 16312-21-3 This article mentions the following:
The pyrimidinethiones I (R = Ph, C6H4Me-p, C6H4NO2–p, C6H4Me-o, Me) were treated with aqueous ClCH2CO2H to give the corresponding thiazolidines II in good yields. The mechanism involves initial condensation of the acid at the S atom, followed by protonation, ring cleavage, cyclodehydration, and hydrolysis to give II. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Recommanded Product: 16312-21-3).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Recommanded Product: 16312-21-3
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com