Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis was written by Dhara, Kalyan;Paladhi, Sushovan;Midya, Ganesh Chandra;Dash, Jyotirmayee. And the article was included in Organic & Biomolecular Chemistry in 2011.Application In Synthesis of 3-Methylthiazolidine-2,4-dione This article mentions the following:
A novel synthetic route to spirocyclic thiazolidinediones is reported by utilizing ring-closing metathesis (RCM). A selective cross metathesis (CM) of N-allyl azaspiro derivatives with different olefins has been demonstrated to prepare substituted azaspiro-[4.4]nonenediones. The X-ray crystal structure of a spirocyclic thiazolidinedione dimer is described, which has been prepared in two steps from thiazolidinedione using a one-pot sequential ring-closing and self metathesis. Cross metathesis proceeds smoothly with both electron rich and poor olefins. The sym. bis-thiazolidinedione spirocyclic system can be used as CM coupling partner with olefins. One-pot sequential RCM-CM has been developed for the synthesis of substituted spirocyclic compounds The methodol. allows a quick access to thiaazaspiro[4.4]nonene and -[4.5]decenedione ring systems from readily available starting materials which are not otherwise accessible. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Application In Synthesis of 3-Methylthiazolidine-2,4-dione).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Application In Synthesis of 3-Methylthiazolidine-2,4-dione
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com