Urbano, Mariangela et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 16312-21-3

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.HPLC of Formula: 16312-21-3

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype was written by Urbano, Mariangela;Guerrero, Miguel;Velaparthi, Subash;Crisp, Melissa;Chase, Peter;Hodder, Peter;Schaeffer, Marie-Therese;Brown, Steven;Rosen, Hugh;Roberts, Edward. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.HPLC of Formula: 16312-21-3 This article mentions the following:

High affinity and selective S1P4 receptor (S1P4-R) small mol. agonists may be important proof-of-principle tools used to clarify the receptor biol. function and effects to assess the therapeutic potential of the S1P4-R in diverse disease areas including treatment of viral infections and thrombocytopenia. A high-throughput screening campaign of the Mol. Libraries-Small Mol. Repository was carried out by our laboratories and identified (2Z,5Z)-5-((1-(2-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methylene)-3-methyl-2-(methylimino) thiazolidin-4-one I as a promising S1P4-R agonist hit distinct from literature S1P4-R modulators. Rational chem. modifications of the hit allowed the identification of a promising lead mol. with low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P1-3,5-Rs family members. The lead mol. herein disclosed constitutes a valuable pharmacol. tool to explore the effects of the S1P4-R signaling cascade and elucidate the mol. basis of the receptor function. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3HPLC of Formula: 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.HPLC of Formula: 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com