PEG-600 mediated one-pot synthesis of quinolinylidenethiazolidinediones as potential anti-hyperglycemic agents was written by Riyaz, Sd;Naidu, A.;Dubey, P. K.. And the article was included in Indian Journal of Chemistry in 2012.Related Products of 16312-21-3 This article mentions the following:
Knoevenagel condensation between quinoline-2-carboxaldehyde (I) and active-methylene-containing 2,4-thiazolidinedione in PEG-600 at 100° for 2 h, without the usage of any base, yields 5-quinolin-2-ylidenethiazolidine-2,4-dione, which on alkylation gives N-substituted derivatives (II). Both the reaction steps can be performed under one-pot conditions. Alternatively, II can also be synthesized by condensation of N-substituted thiazolidine-2,4-dione with I in PEG-600 at 100°C. The α,β-unsaturated carbonyl derivatives II are subjected to C:C reduction using Mg turnings in refluxing EtOH to yield 5-(quinolin-2-ylmethyl)thiazolidine-2,4-diones in high yields, which are novel potential anti-hyperglycemic agents (no data). In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Related Products of 16312-21-3).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Open-chain compounds are obtained when thiazolidines are treated with tris(trimethylsilyl)silane in a reaction in which the thiazolidine derivatives act as a source of α-aminoalkyl radicals.Related Products of 16312-21-3
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com