Synthesis of heterocycles via enamines – X. Reactions of 1-substituted-4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thione derivatives with α-halogenated carboxylic acids and ketones was written by Singh, Harjit;Singh, Paramjit;Deep, Kanwal. And the article was included in Tetrahedron in 1983.Product Details of 16312-21-3 This article mentions the following:
Condensing pyrimidinethiones I (R = Me, 2-, 4-MeC6H4, 4-O2NC6H4, Ph, H) with R1CHClCO2H (R1 = H, Me) in aqueous medium gave 50-90% dioxothiazolidines II. I (R = H, Me, Ph, 4-MeC6H4) and α-halo ketones in EtOH containing concentration HCl gave oxothiazolines III (R2 = Ph, 4-BrC6H4, 4-ClC6H4). Condensing N,N-dialkyl-N‘-arylthioureas or arylthiourethanes with α-chlorocarboxylic acids or derivatives, or α-halo ketone in the presence of conductivity HCl gave II or III, resp. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Product Details of 16312-21-3).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Product Details of 16312-21-3
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com