Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2199-44-2, is researched, SMILESS is O=C(C1=C(C)C=C(C)N1)OCC, Molecular C9H13NO2Journal, Journal of Heterocyclic Chemistry called Microwave-accelerated synthesis of benzyl 3,5-dimethyl-pyrrole-2-carboxylate, Author is Regourd, Jasmine; Comeau, Ian M.; Beshara, Cory S.; Thompson, Alison, the main research direction is ethyl pyrrolecarboxylate benzyl alc transesterification microwave irradiation; acetylpyrrolecarboxylate benzyl deacetylation microwave irradiation; pyrrolecarboxylate benzyl preparation.Name: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.
Benzyl 3,5-dimethyl-pyrrole-2-carboxylate (I), a very useful pyrrole in porphyrin and dipyrromethene synthesis, can be synthesized via the Knorr-type reaction, but in low yield. Alternative routes to I have been developed involving the trans-esterification of Et 3,5-dimethyl-pyrrole-2-carboxylate and the deacetylation of benzyl 4-acetyl-3,5-dimethyl-2-carboxylate, both precursors being easily obtained using the Knorr reaction. These traditional methods involve treatment of the known products with a strong basic solution or heating for extended periods which often lead to decomposition The use of microwave energy to promote these two reactions proves to be an extremely efficient way to obtain I quickly, in high yield, and in excellent purity with no need for recrystallization Of particular note is the use of catalytic sodium methoxide in benzyl alc., rather than stoichiometric amounts of sodium benzoxide, to effect benzylation.
After consulting a lot of data, we found that this compound(2199-44-2)Name: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com