The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.Formula: C9H13NO2.Thompson, Alison; Gao, Susan; Modzelewska, Gosia; Hughes, David S.; Patrick, Brian; Dolphin, David published the article 《x-ray Crystallographic and 13C NMR Investigations of the Effects of Electron-Withdrawing Groups on a Series of Pyrroles》 about this compound( cas:2199-44-2 ) in Organic Letters. Keywords: crystallog carbon NMR electron withdrawing group pyrrole derivative. Let’s learn more about this compound (cas:2199-44-2).
Pyrroles substituted with various electron-withdrawing groups (EWGs) on the N atom were synthesized and full characterization including x-ray crystal structures obtained. Anal. of 13C chem. shifts and x-ray crystal structures reveals that a trend between decreased aromaticity and the strength of the EWG exists. Exptl. results regarding alternative mechanisms of nucleophilic substitution reactions can thus be rationalized.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com