Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2199-44-2, is researched, SMILESS is O=C(C1=C(C)C=C(C)N1)OCC, Molecular C9H13NO2Journal, Justus Liebigs Annalen der Chemie called Dithiocarboxylic acids of pyrroles. II. Friedel-Crafts reactions with carbon disulfide, Author is Treibs, Alfred; Friess, Raimund, the main research direction is pyrrole dithiocarboxylic acid preparation; dithiocarboxylic acid pyrrole preparation; Friedel Crafts reaction carbon disulfide; carbon disulfide Friedel Crafts reaction.Application In Synthesis of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.
Reaction of 2,4-dimethyl-5-(ethoxycarbonyl)pyrrole (I) with AlCl3 in CS2 gave 10% 3-(dithiocarboxy) derivative (II) of I. The same reactions in the presence of ClCO2Et gave the Et ester of II. 2-Methyl-3-(ethoxycarbonyl)pyrrole-5-dithiocarboxylic acid was obtained in 10% yield from 2-methyl-3-(ethoxycarbonyl)pyrrole with AlCl3 and CS2. These reactions show CS2 was not an indifferent solvent in Friedel-Crafts reactions.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com