The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid( cas:63352-97-6 ) is researched.COA of Formula: C10H8BrNO2.Luebbe, Claus; Van Pee, Karl Heinz; Salcher, Olga; Lingens, Franz published the article 《The metabolism of tryptophan and 7-chlorotryptophan in Pseudomonas pyrrocinia and Pseudomonas aureofaciens》 about this compound( cas:63352-97-6 ) in Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie. Keywords: tryptophan chlorotryptophan metabolism Pseudomonas. Let’s learn more about this compound (cas:63352-97-6).
P. pyrrocinia ATCC 15958 and a mutant strain (ACN) of P. aureofaciens ATCC 15926 possess a mechanism for the degradation of the tryptophan side chain. Indole, indole-3-carboxylic acid, indole-3-acetic acid, the corresponding compounds chlorinated or brominated at position 7, indole-3-pyruvate, and 7-chloroindole-3-pyruvate were isolated from bacterial cultures. The chlorinated indole derivatives were isolated after the addition of 7-chloro-DL-tryptophan to cultures of P. pyrrocinia whereas their bromo analogs were found in the culture medium of the mutant strain ACN of P. aureofaciens, grown in the presence of NaBr. Enzymic studies show that tryptophan is transaminated to indole-3-pyruvate, which is transformed to indole-3-acetaldehyde. Dehydrogenation of indole-3-acetaldehyde leads to indole-3-acetic acid, which is further metabolized to indole-3-carboxaldehyde and converted by dehydrogenation to indole-3-carboxylic acid. Indole is formed by the spontaneous decarboxylation of indole-3-carboxylic acid.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com