The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole( cas:15965-55-6 ) is researched.Recommanded Product: 15965-55-6.Ricci, Alfredo; Vivarelli, Piero published the article 《Acid dissociation constants of some benzo-substituted 2-chlorobenzimidazoles》 about this compound( cas:15965-55-6 ) in Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, Supplemento. Keywords: BENZIMIDAZOLES DISSOCN; DISSOCN BENZIMIDAZOLES; CHLOROBENZIMIDAZOLES DISSOCN. Let’s learn more about this compound (cas:15965-55-6).
The measurements of the apparent pK were measured in water with 2% MeOH at a constant ionic strength of 0.5 from derivatives by substitution in the 5(6) and 4(7) positions. The following values were obtained: H, 9.3; 5(6) Me, 9.5; 5(6) Cl, 8.5; 5(6) NO2, 7.4; 4(7) Me, 9.6; 4(7) Cl 8.4; 4(7) NO2 7.5. The acidity justifies the hypothesis that in the presence of methoxy ions the compounds are transformed in the conjugate bases and without nucleophilic reactivity. With piperidine and PhSH the nucleophilic reaction is possible.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com